Journal: International Journal of Molecular Sciences
Article Title: Are the Properties of Bone Marrow-Derived Mesenchymal Stem Cells Influenced by Overweight and Obesity?
doi: 10.3390/ijms24054831
Figure Lengend Snippet: Animal studies included in the review.
Article Snippet: Picke et al. [ ] , C57BL/6J mice , Male , 4–5 weeks , An HFD (EF R/M D12331 diet modified by Surwit, ssniff) or a chow diet for 12 to 20 weeks Note: CD90 knock-out mice on C57BL/6J background and wild-type C57BL/6J mice for functional validation , Tibias and femurs , The similar clonogenic ability between lean and obese BMSCs; reduced CD90 expression in obese BMSCs; CD90-deficient BMSCs have increased adipogenic differentiation, attenuated osteogenic differentiation, and a decreasing trend in apoptosis.
Techniques: Control, Purification, Expressing, Derivative Assay, Modification, Knock-Out, Functional Assay, Biomarker Discovery, Generated, Western Blot, Over Expression, Transgenic Assay